• C-reactive protein and its associations with сardiometabolic risk factors and echocardiographic indicators of heart failure: results of “Know your heart” study in Arkhangelsk 

      Mirolyubova, Olga A.; Kudryavtsev, Alexander V.; Semchyugova, Elvira; Malyutina, Sofia; Ryabikov, Andrey (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09)
      <p><i>Цель - </i>Оценка связи высокочувствительного С-реактивного белка (вчСРБ) с кардиометаболическими и эхокардиографическими (ЭхоКГ) индикаторами сердечной недостаточности (СН) среди взрослого населения Северного региона России. <p><i>Материал и методы - </i>Поперечное исследование «Узнай свое сердце» проведено в 2015–2017 гг. на случайной выборке общего населения г. Архангельска в возрасте 35–69 ...
    • Effect of adiposity on differences in carotid plaque burden in studies conducted in Norway and Russia: a cross-sectional analysis of two populations at very different risk of cardiovascular mortality 

      Imahori, Yume; Frost, Chris; Mathiesen, Ellisiv B.; Ryabikov, Andrey; Kudryavtsev, Alexander V; Malyutina, Sofia; Kornev, Michael; Hughes, Alun D; Hopstock, Laila Arnesdatter; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-06)
      <i>Objectives</i> - Large differences exist in the burden of cardiovascular disease (CVD) between Russia and Western European countries including Norway. Obesity prevalence may contribute to the differences. We investigated whether difference in the level of adiposity, assessed using body mass index and waist-to-hip ratio(WHR), could explain intercountry differences in the burden of carotid plaque, ...
    • External validation of a deep learning electrocardiogram algorithm to detect ventricular dysfunction 

      Attia, Itzhak Zachi; Tseng, Andrew S.; Benavente, Ernest Diez; Medina-Inojosa, Jose R.; Clark, Taane; Malyutina, Sofia; Kapa, Suraj; Schirmer, Henrik; Kudryavtsev, Alexander V; Noseworthy, Peter A.; Carter, Rickey E.; Ryabikov, Andrey; Perel, Pablo; Friedman, Paul A.; Leon, David A.; Lopez-Jimenez, Francisco (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-02)
      Objective - To validate a novel artificial-intelligence electrocardiogram algorithm (AI-ECG) to detect left ventricular systolic dysfunction (LVSD) in an external population.<p> <p>Background - LVSD, even when asymptomatic, confers increased morbidity and mortality. We recently derived AI-ECG to detect LVSD using ECGs based on a large sample of patients treated at the Mayo Clinic.<p> <p>Methods ...
    • Heavy alcohol drinking and subclinical echocardiographic abnormalities of structure and function 

      Iakunchykova, Olena; Schirmer, Henrik; Leong, Darryl; Malyutina, Sofia; Ryabikov, Andrey; Averina, Maria; Kudryavtsev, Alexander V; Kornev, Mikhail; Voronina, Ekaterina; Paramonov, Andrey; Wilsgaard, Tom; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-02)
      Objective - The aim of the study is to assess changes in heart structure and function associated with heavy alcohol use by comparing echocardiographic indices in a population-based sample to those in patients admitted to an inpatient facility with severe alcohol problems.<p> <p>Methods and results - We used data from the Know Your Heart study (2015–2017) which is a cross-sectional study that ...
    • Studying accelerated cardiovascular ageing in Russian adults through a novel deep-learning ECG biomarker 

      Benavente, Ernest Diez; Jimenez-Lopez, Francisco; Attia, Zachi I.; Malyutina, Sofia; Kudryavtsev, Alexander; Ryabikov, Andrey; Friedman, Paul A.; Kapa, Suraj; Voevoda, Michael; Perel, Pablo; Schirmer, Henrik; Hughes, Alun D.; Clark, Taane; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-25)
      Background: A non-invasive, easy-to-access marker of accelerated cardiac ageing would provide novel insights into the mechanisms and aetiology of cardiovascular disease (CVD) as well as contribute to risk stratification of those who have not had a heart or circulatory event. Our hypothesis is that differences between an ECG-predicted and chronologic age of participants (δage) would reflect accelerated ...
    • Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds 

      Petersen, Jakob; Malyutina, Sofia; Ryabikov, Andrey; Kontsevaya, Anna; Kudryavtsev, Alexander V; Eggen, Anne Elise; McKee, Martin; Cook, Sarah Anne; Hopstock, Laila Arnesdatter; Schirmer, Henrik; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-13)
      <i>Background</i> - Uncontrolled hypertension is a major cardiovascular risk factor. We examined uncontrolled hypertension and differences in treatment regimens between a high-risk country, Russia, and low-risk Norway to gain better understanding of the underlying factors.<p><p> <i>Methods</i> - Population-based survey data on 40–69 year olds with hypertension defined as taking antihypertensives ...